Mutational and functional analysis of Large in a novel CHO glycosylation mutant
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چکیده
منابع مشابه
Mutational and functional analysis of Large in a novel CHO glycosylation mutant.
Inactivating mutations of Large reduce the functional glycosylation of alpha-dystroglycan (alpha-DG) and lead to muscular dystrophy in mouse and humans. The N-terminal domain of Large is most similar to UDP-glucose glucosyltransferases (UGGT), and the C-terminal domain is related to the human i blood group transferase beta1,3GlcNAcT-1. The amino acids at conserved motifs DQD+1 and DQD+3 in the ...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2009
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwp074